Wedelolactone ameliorates synovial inflammation and cardiac complications in a murine model of collagen-induced arthritis by inhibiting NF-κB/NLRP3 inflammasome activation.

Jingjing Cao,Yanhui Ni,Xiaoran Ning,Huaxing Zhang

Folia histochemica et cytobiologica（2022）

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摘要

These findings suggested that Wed attenuated synovial inflammation and joint damage in a mouse model of RA via inhibiting NF-κB/NLRP3 inflammasome activation, and ameliorated RA-induced cardiac complications.

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关键词

NF-κB,NLRP3,cardiac fibrosis,collagen-induced arthritis,mouse,wedelolactone

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