Silencing RIPK1/mTORC1 signalling attenuated the inflammation and oxidative stress in diabetic cardiomyopathy

Experimental Cell Research(2023)

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摘要
Overall, RIPK1/mTORC1 signalling suppression improved HG-induced apoptosis, inflammation and oxidative stress through activation autophagy. These data provided a reliable evidence that RIPK1 may be a potential target for DCM therapeutic.
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关键词
Diabetes cardiomyopathy,Receptor-interacting protein kinase 1,Mammalian target of rapamycin complex 1,Autophagy,Diabetes mellitus
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