In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns.

Ágata Lopes-Ribeiro,Franklin Pereira Araujo,Patrícia de Melo Oliveira,Lorena de Almeida Teixeira,Geovane Marques Ferreira,Alice Aparecida Lourenço, Laura Cardoso Corrêa Dias, Caio Wilker Teixeira, Henrique Morais Retes,Élisson Nogueira Lopes,Alice Freitas Versiani,Edel Figueiredo Barbosa-Stancioli,Flávio Guimarães da Fonseca,Olindo Assis Martins-Filho,Moriya Tsuji,Vanessa Peruhype-Magalhães,Jordana Grazziela Alves Coelho-Dos-Reis

Frontiers in immunology（2022）

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摘要

To our knowledge, these results provide the most comprehensive and detailed snapshot of the immunodominant peptide signature for arbovirus with MHC-class I restriction, which may bring insight into the design of future virus-specific vaccines to arboviruses and for vaccination protocols in highly endemic areas.

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关键词

CD8+T cell response,HLA-A2-restricted peptides,MHC-I peptides,arbovirus,immunoinformatics,overlapping peptides

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