Quantitative analysis of drug distribution in heterogeneous tissues using dual-stacking capillary electrophoresis-mass spectrometry.

Shigehiro Koganemaru,Takayuki Kawai,Hirobumi Fuchigami,Naoyuki Maeda,Kumiko Koyama,Yasutoshi Kuboki,Toru Mukohara,Toshihiko Doi,Masahiro Yasunaga

British journal of pharmacology（2023）

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摘要

Our LDMS-CE-MS successfully visualized the attomole-level drug distributions in heterogeneous clinical specimens. This new platform opens a new era of quantitative pharmacokinetic analysis, facilitating drug discovery and development.

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关键词

antibody-drug conjugate,bystander effect,capillary electrophoresis-mass spectrometry,in situ tissue pharmacokinetic analysis,tumour heterogeneity

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