Novel 6-amino-1,3,5-triazine derivatives as potent BTK inhibitors: structure-activity relationship (SAR) analysis and preliminary mechanism investigation

•A series of Novel 6-amino-1,3,5-triazine scaffold-based BTK irreversible inhibitors.•Representative compound C11 potently blocked activation of BTK and downstream signaling.•Compound C11 induced G1 cell cycle arrest and apoptosis in Raji cells.•Compound C11 exhibited high BTK selectivity over EGFR in enzyme level.