Treatment of Cushing Disease With Pituitary-Targeting Seliciclib.

Ning-Ai Liu,Anat Ben-Shlomo,John D Carmichael,Christina Wang,Ronald S Swerdloff,Anthony P Heaney,Garni Barkhoudarian,Daniel Kelly,Mazen Noureddin,Lin Lu, Manish Desai, Yana Stolyarov,Kevin Yuen,Adam N Mamelak,James Mirocha,Mourad Tighiouart,Shlomo Melmed

The Journal of clinical endocrinology and metabolism（2023）

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摘要

Seliciclib may directly target pituitary corticotrophs in CD and reverse hypercortisolism. Potential liver toxicity of seliciclib resolves with treatment withdrawal. The lowest effective dose requires further determination.

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关键词

Cushing disease,adrenocorticotrophic hormone,cortisol,pituitary adenoma

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