Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.

Ying Chen,Lei Wang,Zhan-Sen Huang,Jia-Xin Feng,Shi-Xiong Li,Zi-Jun Du,Ze-Bo Zhang,Jing Liu,Jian Yang,Zhi-Ming Hu,Zhi-Lin Wang,Jun Chen

Andrology（2023）

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摘要

The down-regulation of SPTA1 in SD rats fed with HFD may induce cell pyroptosis and lead to the decrease of erectile function by activating the Hippo pathway; these findings may provide new therapeutic targets for improving erectile function.

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关键词

Hippo signalling pathway,SPTA1,cell pyroptosis,erectile function decreased,high-fat diet

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