In Vitro Model Systems to Study Human T Cell Development.

Nina Lambrechts,Kai Ling Liang,Imke Velghe,Steven Strubbe,Anne-Catherine Dolens,Tom Taghon

Methods in molecular biology (Clifton, N.J.)（2023）

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摘要

Not only is human T cell development characterized by unique changes in surface marker expression, but it also requires specific growth factors and conditions to mimic and study T cell development in vitro. In this chapter, we provide an overview of the specific aspects that need attention when performing T cell differentiation cultures with human hematopoietic and T cell progenitors.

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关键词

Artificial thymic organoid,Gene perturbation,Hematopoietic stem cell,Human,In vitro,Lineage differentiation,OP9 co-culture,T cell development,Viral transduction

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