Sex Is the Main Determinant of Levodopa Clinical Pharmacokinetics: Evidence from a Large Series of Levodopa Therapeutic Monitoring.

Manuela Contin,Giovanna Lopane,Laura M B Belotti, Margherita Galletti,Pietro Cortelli,Giovanna Calandra-Buonaura

Journal of Parkinson's disease（2022）

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摘要

This is the largest collection of data on the relationship between demographic and clinical-therapeutic variables and LD kinetics in patients with parkinsonian symptoms. As a main clinically practical finding, women might require a 25% reduced weight-normalized LD dose compared with men to achieve the same LD bioavailability.

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关键词

Levodopa,dopa decarboxylase inhibitors,levodopa therapeutic monitoring,levodopa-induced dyskinesias,pharmacodynamics,pharmacokinetics,sex

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