Hippocampal CB1 receptor mediates antidepressant-like effect of synthetic cannabinoid-HU210 in acute despair reaction model in mice

•Acute stress induced a significant increase in depression-like behaviors.•HU210 dose dependently blocked acute stress-induced depression-like behaviors.•Systemic administration of AM251 attenuated anti-depression like effects of HU210.•Inhibition of Hippocampal LTD reversed anti-depression like action of HU210.