A simple protein histidine kinase activity assay for high-throughput inhibitor screening

Donghee Lee,Yunmi Lee, Son Hye Shin, Su Min Choi, Shin Hyeon Lee,Seonghun Jeong,Soojin Jang,Jung-Min Kee

Bioorganic Chemistry（2023）

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摘要

•A simple assay, AUDECY, to measure histidine kinase activity is developed.•AUDECY-based high-throughput screening identified VanS inhibitors.•Identified VanS inhibitors showed efficacy to vancomycin-resistant Enterococci.

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关键词

Histidine kinase,Antibacterial,High-throughput screening,Vancomycin resistance,ESKAPE pathogens

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