Fabrication, characterization, and in vitro evaluation of doxorubicin-coupled chitosan oligosaccharide nanoparticles

Guo Yi,Junhong Ling,Yongjun Jiang,YuQing Lu,Li-Ye Yang,Xiao-kun Ouyang

Journal of Molecular Structure（2022）

引用 9|浏览15

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摘要

•Nanoparticles conjugated with DOX and COS via DF-PEG-DF.•Nanoparticles showed significant pH sensitivity on in vitro release assays.•Introduction of COS increases the biocompatibility and solubility of DOX.•Nanoparticles have a good potential as lipid-soluble drug carriers.

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关键词

Chitosan oligosaccharide,DOX,pH-sensitive release

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