Potassium Persulfate/Tributylamine-Mediated Alkylation/Annulation of N-Arylacrylamides with Alkyl Iodides

Huimin Chen,Zetian Sun, Hui Yang,Fenghua Mao,Xinhuan Yan,Xiaoqing Li,Xiangsheng Xu

SYNLETT（2023）

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摘要

We report a catalyst-free method for the alkylation/annulation of N-arylacrylamides to give the corresponding 3-alkyl-2-oxo-2,3-dihydro-1H-indoles by using alkyl iodides as precursors of alkyl radicals. These reactions occur at moderate temperatures and are mediated by easily accessible K2S2O8 and Bu3N.

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关键词

arylacrylamides,cyclization,oxindoles,halogen-atom transfer,alkylation

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