Impact of EGFRA289T/V mutation on relapse pattern in glioblastoma

A. Noeuveglise, N. Sarafan-Vasseur,L. Beaussire,F. Marguet,R. Modzelewski,C. Hanzen,C. Alexandru,N. Magne,O. Langlois,F. Di Fiore,F. Clatot,S. Thureau,M. Fontanilles

JOURNAL OF CLINICAL ONCOLOGY（2023）

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摘要

•EGFRA298mut impact on relapse pattern is independent of EGFR amplification, EGFRvIII and other extracellular domain mutations.•EGFRA289mut doesn't impact survival in our study.•The clinical utility of EGFRA298mut as potential biomarker needs to be explored in further studies.

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关键词

glioblastoma,relapse pattern,EGFR,mutation,overlap score,radiotherapy

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