Structural Insights into the Mechanism of HIV-1 Tat Secretion from the Plasma Membrane

Ruba H Ghanam,Gunnar N Eastep,Jamil S Saad

Journal of Molecular Biology（2023）

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摘要

•Molecular determinants of HIV-1 Tat binding to membrane are defined.•The Arg49-Lys50-Lys51 (RKK) motif is the PI(4,5)P2 binding site.•The arginine-rich motif preferentially binds to phosphatidylserine.•Trp11 is a critical residue for membrane penetration.

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关键词

HIV-1,Tat,PI(4,5)P2,membrane,secretion

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