Landscape and clinical impact of NOTCH mutations in newly diagnosed acute myeloid leukemia.

Although NOTCH mutations (NOTCH ) are well studied in T-cell acute lymphoblastic leukemia (T-ALL), less is known about their incidence and prognostic implications in acute myeloid leukemia (AML). A total of 878 newly diagnosed patients with AML was retrospectively analyzed; it was found that the frequency of NOTCH was relatively low but was associated with an adverse prognosis.