A Tracheal Aspirate-Derived Airway Basal Cell Model Reveals a Proinflammatory Epithelial Defect in Congenital Diaphragmatic Hernia.

Richard Wagner,Gaurang M Amonkar,Wei Wang,Jessica E Shui,Kamakshi Bankoti,Wai Hei Tse,Frances A High,Jill M Zalieckas,Terry L Buchmiller,Augusto Zani,Richard Keijzer,Patricia K Donahoe,Paul Hubert Lerou,Xingbin Ai

American journal of respiratory and critical care medicine（2023）

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摘要

Our findings have identified an underlying proinflammatory signature and BSC differentiation defects as a potential therapeutic target for airway epithelial defects in CDH.

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关键词

Congenital Diaphragmatic Hernia,Inflammatory gene expression signature,Lung Hypoplasia,Nitrofen Rat Model,Tracheal Aspirate derived lung progenitor cells

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