Increase of mast cells in COVID-19 pneumonia may contribute to pulmonary fibrosis and thrombosis.

Leonoor V Wismans,Boaz Lopuhaä,Willem de Koning,Hazra Moeniralam, Matthijs van Oosterhout, Carmen Ambarus, Frederik N Hofman,Thijs Kuiken,Henrik Endeman,Dana A M Mustafa,Jan H von der Thüsen

Histopathology（2023）

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摘要

Two separate means of measuring show a significant increase of mast cells in SARS-CoV-2-infected lung tissue compared to influenza. Additionally, several genes involved in fibrosis and thrombosis, among which are RAGE and PPBP, are up-regulated in COVID-19. As mast cells are able to induce thrombosis and fibrosis, they may play an important role in the pathogenesis of COVID-19.

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关键词

COVID-19,autoimmunity,fibrosis,gene expression profiling,genomics,mast cells,thrombosis

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