Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification.

Circulation research（2022）

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摘要

Nidogen-2 is a novel endogenous ligand of LGR4 that biased activated Gαq- PKCα-AMPKα1 signaling and inhibited vascular calcification.

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关键词

LGR4,extracellular matrix,nidogen-2,smooth muscle cells,vascular calcification

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