Oncolytic herpes simplex virus delivery of dual CAR targets of CD19 and BCMA as well as immunomodulators to enhance therapeutic efficacy in solid tumors combined with CAR T cell therapy.

Yuanyuan Liu,Yanxin Zheng, Tianyi Deng,Yue Huang,Ziwen Liu,Borui Zhan,Xusha Zhou,Runbin Yan,Jiangtao Ren, Yun Xing, Guixing Wu, Biao Zheng,Guang Hu,Wen Wang,Yonghong Liu,Jing Zhao,Xiaoqing Chen,Grace Guoying Zhou

Frontiers in oncology（2022）

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摘要

These studies indicated that the new generation of oHSV T7011 can be a promising combinational therapy with CD19 or BCMA-specific CAR T cells for the treatment of a broad range of solid tumors.

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关键词

BCMA,CAR T-cell treatment,CD19,oHSV,solid tumor

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