Malondialdehyde acetaldehyde adduction of surfactant protein D attenuates SARS-CoV-2 spike protein binding and virus neutralization.

Abenaya Muralidharan,Christopher Bauer,Dawn M Katafiasz, Danielle Pham,Opeoluwa O Oyewole,M Jane Morwitzer,Enakshi Roy,Kristina L Bailey,St Patrick Reid,Todd A Wyatt

Alcoholism, clinical and experimental research（2023）

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摘要

Overall, MAA adduction of SPD, a consequence of alcohol overconsumption, represents one mechanism of compromised lung innate defense against SARS-CoV-2, highlighting a possible mechanism underlying COVID-19 severity and related mortality in patients who misuse alcohol.

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SARS-CoV-2,alcohol,cigarette smoke,lung immunity,malondialdehyde acetaldehyde,surfactant protein D

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