Molecular characterization of immune checkpoint inhibitor-induced cardiotoxicity reveals IL-17A as a driver of cardiac dysfunction after anti-PD-1 treatment

Tamas G. Gergely,Daniel Kucsera,Viktoria E. Toth,Tamas Kovacs,Nabil V. Sayour,Sofia D. Drobni,Mihaly Ruppert,Balazs Petrovich,Bence Agg,Zsofia Onodi,Nora Fekete,Eva Pallinger,Edit I. Buzas,Laura I. Yousif,Wouter C. Meijers,Tamas Radovits,Bela Merkely,Peter Ferdinandy,Zoltan Varga

British Journal of Pharmacology（2023）

引用 6|浏览16

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摘要

PD-1 blockade induces cardiac dysfunction in mice with increased IL-17 signalling in the thymus. Pharmacological inhibition of IL-17A treatment prevents ICI-induced cardiac dysfunction.

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关键词

cancer immunotherapy,cardio-oncology,cardiotoxicity,heart failure,nivolumab,pembrolizumab

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