Serum inflammatory and brain injury biomarkers in COVID-19 patients admitted to intensive care unit: A pilot study.

Stelios Kokkoris,Elisavet Stamataki, Giorgos Emmanouil,Christina Psachoulia,Theodora Ntaidou, Aikaterini Maragouti, Angeliki Kanavou,Sotirios Malachias, Foteini Christodouli,Ioannis Papachatzakis,Vassiliki Markaki,Dimitrios Katsaros,Ioannis Vasileiadis,Constantinos Glynos,Christina Routsi

eNeurologicalSci（2022）

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摘要

Brain injury biomarkers were frequently elevated in COVID-19 ICU patients, in the absence of clinical evidence of brain injury. S100B was significantly correlated with IL-6, low lymphocyte count, hypoperfusion indices, illness severity, and short-term outcome. These findings indicate a possible brain astrocytes and neurons involvement, also suggesting a broader role of S100B in systemic inflammatory response.

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关键词

Brain injury markers,COVID-19,Critically ill,ICU,IL-6,Inflammation,NSE,Neuroinflammation,S100B,SARS-CoV2,Shock,Tissue perfusion

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