Cross-kingdom RNAi to enhance the efficacy of insect pathogens

Insect pathogens play significant roles in the biocontrol of medical and agricultural pests. Cui et al. demonstrated that genetically modified (GM) fungi expressing host mosquito miRNAs could enhance the efficacy of the fungus by suppressing the host immune response. This opens avenues for utilisation of cross-kingdom RNAi in biocontrol.