AhR regulates VEGF expression by promoting STAT1 transcriptional activity, thereby affecting endothelial angiogenesis in acute limb ischemia

Jinhui Ma,Jiangbo Chen, Heng Wang,Danghui Lu,Kai Liang

Chemico-Biological Interactions（2023）

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摘要

•STAT1 was up-regulated in ALI models.•AhR could bind directly to the STAT1 promoter in ischemic diseases of lower limbs.•In ALI models, the deficiency of AhR promoted angiogenesis and blood flow recovery.

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关键词

Acute limb ischemia,AhR,STAT1,VEGF,Angiogenesis

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