Plasma S1P and sphingosine are not different prior to preeclampsia in women at high risk of developing the disease.

Previous studies have suggested that plasma S1P maybe a biomarker of preeclampsia. In our larger study we failed to demonstrate this is women at high risk of developing the disease. We did not show a relationship with known biomarkers of the disease, suggesting that S1P is unlikely to be a useful predictor of the development of preeclampsia later in pregnancy.