Effect of Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Booster on Human Immunodeficiency Virus Reservoirs and Immune Markers.

M Ali Rai,Victoria Shi,Brooke D Kennedy,Jesse S Justement,Kathleen Gittens,Genevieve McCormack,Jana Blazkova,Susan Moir,Tae-Wook Chun

Open forum infectious diseases（2022）

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摘要

We investigated effects of the severe acute respiratory syndrome coronavirus 2 (SARV-CoV-2) booster vaccination on human immunodeficiency virus (HIV) reservoir size, immune markers, and host immune responses in people with HIV receiving antiretroviral therapy. Our data suggest that the SARS-CoV-2 booster vaccine is not likely to replenish the persistent HIV reservoir nor provide an immunologic environment to facilitate active HIV expression/replication.

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HIV,HIV reservoirs,SARS-CoV-2,booster vaccine,immune markers and responses

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