Serological responses to the MVA-based JYNNEOS monkeypox vaccine in a cohort of participants from the Democratic Republic of Congo

Lalita Priyamvada,William C. Carson,Eddy Ortega, Terese Navarra, Stephanie Tran,Todd G. Smith,Elisabeth Pukuta,Elisabeth Muyamuna,Joelle Kabamba,Beatrice U. Nguete,Toutou Likafi, Gaston Kokola,Robert Shongo Lushima,Jean-Jacques Muyembe Tamfum,Emile W. Okitolonda, Didine K. Kaba,Benjamin P. Monroe,Andrea M. McCollum,Brett W. Petersen,Panayampalli S. Satheshkumar

Vaccine（2022）

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摘要

•JYNNEOS vaccination produces robust anti-orthopoxvirus antibody response.•Naive vaccinees generate OPXV-specific IgM early after vaccination.•IgG responses peak around 2 weeks after second vaccine dose.•Titers wane at 2 years, and more rapidly in naïve vaccinees.•Antibodies neutralize VACV and MPXV differently, but had similar rise from baseline.

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关键词

JYNNEOS,MVA,Monkeypox,Orthopoxvirus,Serology,Antibody,Immunogenicity

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