Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics.

Florian Heinkel,Meghan M Verstraete, Siran Cao,Janessa Li,Patrick Farber,Elizabeth Stangle,Begonia Silva-Moreno,Fangni Peng,Surjit Dixit,Martin J Boulanger,Thomas Spreter Von Kreudenstein,Eric Escobar-Cabrera

mAbs（2022）

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摘要

ABBREVIATIONS:CE-SDS: capillary electrophoresis sodium dodecyl sulfate; DSC: differential scanning calorimetry; FACS: fluorescence-activated cell sorting; FSA: full-sized antibody; Her2: human epidermal growth factor receptor 2; MFI: mean fluorescent intensity; OAA: one-armed antibody; PBS: phosphate-buffered saline; PDB: Protein Data Bank; SEC: size-exclusion chromatography; prepSEC (preparative SEC); RMSD: root-mean-square deviation; RU: resonance units; SPR: surface plasmon resonance; TAA: tumor-associated antigen; WT: wild-type.

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