T cell-inflamed gene expression profile is associated with favorable disease-specific survival in non-hypermutated microsatellite-stable colorectal cancer patients.

Hang Yin,Tabitha A Harrison,Sushma S Thomas,Cassie L Sather,Amanda L Koehne,Rachel C Malen,Adriana M Reedy,Michelle A Wurscher,Li Hsu,Amanda I Phipps,Syed H E Zaidi,Polly A Newcomb,Ulrike Peters,Jeroen R Huyghe

Cancer medicine（2023）

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摘要

Our results show that the T cell-inflamed GEP is a prognostic biomarker in non-hypermutated microsatellite-stable CRC. This also suggests that patient stratification for immunotherapy within this CRC subgroup should be explored further. Moreover, reported immune-inhibitory gene expression signals may suggest targets for therapeutic combination with immunotherapy.

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关键词

T-cell inflammation,colorectal cancer,gene expression profile,somatic mutation,survival

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