Blocking MG53 S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury.

Fengxiang Lv,Yingfan Wang,Dan Shan,Sile Guo,Gengjia Chen,Li Jin,Wen Zheng,Han Feng, Xiaohu Zeng,Shuo Zhang,Yan Zhang,Xinli Hu,Rui-Ping Xiao

Circulation research（2022）

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摘要

S255 phosphorylation is a biased regulation of MG53 E3 ligase activity. The MG53-S255A mutant provides a promising approach for the treatment of acute myocardial injury, especially in patients with metabolic disorders.

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关键词

GSK3β,MG53,cardiac ischemia/reperfusion injury,cardioprotection,insulin resistance

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