A Combination of Native LC-MS Approaches for the Comprehensive Characterization of the Antibody-Drug Conjugate Trastuzumab Deruxtecan.

Evolène Deslignière,Hélène Diemer,Stéphane Erb,Pierre Coliat,Xavier Pivot,Alexandre Detappe,Oscar Hernandez-Alba,Sarah Cianférani

Frontiers in bioscience (Landmark edition)（2022）

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摘要

This study illustrates the strengths and drawbacks of each LC-nMS coupling. By combining SEC-, HIC-, and CEX-nMS, we were able to achieve a comprehensive characterization of T-DXd without extensive sample preparation prior to MS analysis.

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关键词

antibody-drug conjugate (ADC),biotherapeutics,cation exchange chromatography (CEX),higher order structures,hydrophobic interaction chromatography (HIC),liquid chromatography (LC),native mass spectrometry (MS),size exclusion chromatography (SEC)

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