Imputation of Human Primary Osteoblast Single Cell RNA-Seq Data Identified Three Novel Osteoblastic Subtypes.

Hui-Xi Zhang,Chong Cao,Xiao-Hua Li,Yan Chen,Yue Zhang,Ying Liu,Yun Gong,Xiang Qiu,Cui Zhou,Yu Chen,Zun Wang,Jun-Xiao Yang,Liang Cheng,Xiang-Ding Chen,Hui Shen,Hong-Mei Xiao,Li-Jun Tan,Hong-Wen Deng

Frontiers in bioscience (Landmark edition)（2022）

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摘要

Our findings provided a new perspective for studying the osteoblast heterogeneity and potential biological functions of these freshly isolated human osteoblasts at the single-cell level, which provides further insight into osteoblasts subtypes under various (pathological) physiological conditions.

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关键词

adipose differentiation,immune regulation,imputation,osteoblast heterogeneity,osteoclast differentiation,single-cell RNA sequencing (scRNA-seq)

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