Association of Growth Differentiation Factor 15 with Arterial Stiffness and Endothelial Function in Subpopulations of Patients with Coronary Artery Disease: A Proof-of-Concept Study.

Konstantinos Mourouzis,Gerasimos Siasos,Nikoleta Bozini,Evangelos Oikonomou,Marina Zaromitidou,Vasiliki Tsigkou,Eleni Kokkou,Evanthia Bletsa,Panagiota Stampouloglou,Manolis Vavuranakis,Dimitris Tousoulis

Recent advances in inflammation & allergy drug discovery（2022）

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摘要

This proof-of-concept study showed that higher circulating levels of GDF-15, an inflammatory biomarker, were associated significantly with increased arterial stiffness only in AMI patients, whereas elevated GDF-15 demonstrated a linear relationship with the severity of the myocardial injury.

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关键词

Coronary artery disease,FMD,GDF-15,PWV,acute coronary syndrome,arterial stiffness,augmentation index,endothelial dysfunction,inflammation.,non-obstructive CAD

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