M13, an anthraquinone compound isolated from Morinda officinalis promotes the osteogenic differentiation of MSCs by targeting Wnt/β-catenin signaling

Chuan Li,Liru Tian,Yihai Wang,Huan Luo,Jia Zeng,Peiqiang Su,Shulin Chen,Zhiheng Liao,Weimin Guo,Xiangjiu He,Shuqing Chen,Caixia Xu

Phytomedicine（2023）

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摘要

•M13 promotes MSCs proliferation.•M13 significantly increases the osteogenic differentiation of MSCs.•M13 strongly interacts with the docking site of the WNT signaling complex.•M13 enhances the osteogenic differentiation of MSCs via activation of the Wnt/β-catenin signaling pathway.•M13 is a target candidate for osteoporosis treatment.

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关键词

Morinda officinalis,Anthraquinone,Osteoporosis,MSCS,Wnt/β-catenin,Osteogenic

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