Meta-Chlorophenylpiperazine-Induced Behavioral Changes in Obsessive-Compulsive Disorder Research: A Systematic Review of Rodent Studies

Jéssica Fernandes da Silva, Leticia Mitsuko Taguchi,Erinete da Silva Leite,Amanda Ribeiro de Oliveira

Neuroscience（2022）

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摘要

•We reviewed publications reporting OCD-related mCPP effects on rodents.•Most studies used mCPP 1.0 mg/kg administered acutely, i.p., in adult male rats.•Increased defensive and compulsive behaviors are commonly seen with mCPP.•mCPP also often decreases locomotor activity.•More studies with females and assessing other features of OCD are still needed.

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关键词

Obsessive-Compulsive Disorder,Meta-chlorophenylpiperazine,Serotonin,Rodents,Repetitive behavior,Anxiety

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