The human batokine EPDR1 regulates β-cell metabolism and function

Luis Rodrigo Cataldo,Qian Gao, Lidia Argemi-Muntadas,Ondrej Hodek,Elaine Cowan, Sergey Hladkou,Sevda Gheibi,Peter Spégel,Rashmi B. Prasad,Lena Eliasson,Camilla Scheele,Malin Fex,Hindrik Mulder,Thomas Moritz

Molecular Metabolism（2022）

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摘要

•EPDR1 expression is upregulated in pancreatic islets from obese and T2D donors.•EPDR1 positively regulates insulin secretion in human pancreatic islets and β-cell lines.•EPDR1 promotes the coupling of glycolisis to mitochondrial TCA cycle.•EPDR1 is required for the glucose-stimulated increases of cytosolic ATP/ADP-ratio.

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关键词

Mitochondrial metabolism,Lactate,TCA cycle,Beta cells,Insulin secretion,Type 2 diabetes

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