Polydatin protects against gouty nephropathy by inhibiting renal tubular cell pyroptosis.

Xingliang Shi,Lili Zhuang,Zeqing Zhai,Yi He,Erwei Sun

International journal of rheumatic diseases（2023）

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摘要

The results suggest that PD has a protective effect on mice with GN, which may be related to the downregulation of NLRP3, GSDMD, and caspase-1 proteins and the inhibition of renal tubular epithelial cells pyroptosis.

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关键词

NOD-like receptor protein 3,gasdermin D,gouty nephropathy,polydatin,pyroptosis

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