Release kinetics of [lidocainium][ibuprofenate] as Active Pharmaceutical Ingredient-Ionic Liquid from a plasticized zein matrix in simulated digestion

•Zein-based matrices are formed with plasticizing ionic liquid and glycerol.•The active ingredients keep their biological activity after thermal treatment.•The release of [Lidocainium] and [Ibuprofenate] is studied under digestive conditions.•Zein matrices undergo gastric and intestinal phases without noticeable erosion.•Release kinetics are controlled by diffusion and swelling mechanisms.