A meta-analysis of methotrexate polyglutamates in relation to efficacy and toxicity of methotrexate in inflammatory arthritis, colitis and dermatitis.

Maartje M van de Meeberg,Renske C F Hebing,Michael T Nurmohamed,Herma H Fidder,Martijn W Heymans,Gerd Bouma,Marjolein S de Bruin-Weller,Janneke Tekstra,Bart van den Bemt,Robert de Jonge,Maja Bulatović Ćalasan

British journal of clinical pharmacology（2023）

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摘要

We showed that higher concentrations of erythrocyte MTX-PG were associated with lower disease activity in RA, JIA and psoriasis. These findings are an important step towards implementation of TDM for MTX treatment across IMIDs.

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关键词

immune-mediated inflammatory diseases,methotrexate,pharmacodynamics,therapeutic drug monitoring

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