Relationships Between Telomere Length, Plasma Glucagon-like Peptide 1, and Insulin in Early-Life Stress-Exposed Nonhuman Primates.

Kathryn K Ridout,Shariful A Syed,Hung-Teh Kao,Barbara Porton,Anna V Rozenboym,Jean Tang,Sasha Fulton,Tarique Perera,Andrea P Jackowski,John G Kral,Audrey R Tyrka,Jeremy Coplan

Biological psychiatry global open science（2022）

引用 6|浏览8

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摘要

Unexpectedly, VFD was associated with longer adult telomere length. Insulin resistance may lead to higher pGLP-1 levels in adolescence, which could protect telomere length in VFD offspring as adults. Associations between adult telomere length and adolescent insulin resistance and high pGLP-1 may reflect an adaptive, compensatory response after early-life stress exposure.

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关键词

Adaptive calibration,Adversity,Early-life stress,Insulin,Maltreatment,Telomere,pGLP-1

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