Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions

David R. Brenes,Allison J. Nipper,Melody T. Tan,Frederico O. Gleber-Netto,Richard A. Schwarz,Curtis R. Pickering,Michelle D. Williams,Nadarajah Vigneswaran,Ann M. Gillenwater,Andrew G. Sikora,Rebecca R. Richards-Kortum

Oral Oncology（2022）

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摘要

•It is a challenge to assess risk of progression of oral lesions with mild dysplasia.•Optical imaging can aid in early detection of oral lesions with severe dysplasia.•We compared optical markers and gene expression for mild and severe oral dysplasia.•Optical marker positive mild dysplasia is genetically similar to severe dysplasia.

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关键词

Oral cancer,Gene expression analysis,Oral lesion,Dysplasia,Optical imaging

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