High performance liquid chromatography–tandem mass spectrometry quantification of tryptophan metabolites in human serum and stool – Application to clinical cohorts in Inflammatory Bowel Diseases

Aurore Desmons,Lydie Humbert,Thibaut Eguether,Pranvera Krasniqi,Dominique Rainteau, Tarek Mahdi,Nathalie Kapel,Antonin Lamazière

Journal of Chromatography A（2022）

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摘要

•A LC-MS/MS quantitative method was developed for tryptophan and 20 tryptophan-related metabolites.•References values were determined in healthy human serum and stool samples.•A proof of concept study with IBD patients was performed to validate the method.•Significant variations of tryptophan metabolites between control and IBD patients.

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关键词

tryptophan metabolites profile,LC-MS/MS,Inflammatory bowel diseases

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