Association of Pediatric Buccal Epigenetic Age Acceleration With Adverse Neonatal Brain Growth and Neurodevelopmental Outcomes Among Children Born Very Preterm With a Neonatal Infection.

Noha Gomaa,Chaini Konwar,Nicole Gladish,Stephanie H Au-Young,Ting Guo,Min Sheng,Sarah M Merrill,Edmond Kelly,Vann Chau,Helen M Branson,Linh G Ly,Emma G Duerden,Ruth E Grunau,Michael S Kobor,Steven P Miller

JAMA network open（2022）

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摘要

This cohort study of very preterm neonates suggests that biological aging may be associated with impaired brain growth and neurodevelopmental outcomes. The associations between epigenetic aging and adverse neonatal brain health warrant further attention.

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adverse neonatal brain growth,neurodevelopmental outcomes

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