Multifaceted Effects and Mechanisms of N-Acetylcysteine on Intestinal Injury in a Porcine Epidemic Diarrhea Virus-Infected Porcine Model.

Qian Zhang,Peng Li,Hanbo Li,Dan Yi,Shuangshuang Guo,Lei Wang,Di Zhao,Chao Wang,Tao Wu,Yongqing Hou

Molecular nutrition & food research（2022）

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摘要

NAC administration alleviates PEDV-induced intestinal injury by inhibiting inflammatory responses and improving substance transport, but promotes viral replication by inhibiting interferon signaling. These results suggest NAC exhibits multifaceted effects upon PEDV infection, and thus caution is required when using NAC as a dietary supplement to prevent viral infection.

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关键词

N-acetylcysteine,interferon,intestine,mechanisms,piglets,porcine epidemic diarrhea virus

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