Endogenous SOD2 (Superoxide Dismutase) Regulates Platelet-Dependent Thrombin Generation and Thrombosis During Aging.

Vijay K Sonkar,Alicia S Eustes,Azaj Ahmed,Melissa Jensen, Mitali V Solanki,Jagadish Swamy,Rahul Kumar,Trevor P Fidler,Jon C D Houtman,Bryan G Allen,Douglas R Spitz,E Dale Abel,Sanjana Dayal

Arteriosclerosis, thrombosis, and vascular biology（2022）

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摘要

Platelet mitochondrial ROS contributes to age-related thrombosis and endogenous SOD2 protects from platelet-dependent thrombin generation and thrombosis during aging.

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关键词

aging,genotype,mice,mitochondria,thrombin

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