Data-driven generation of 4D velocity profiles in the aneurysmal ascending aorta

•Statistical shape modeling of 4D velocity profiles in the ascending aorta is a feasible approach to generate realistic synthetic inflow boundary condition data.•The average velocity profile in the aneurysmal ascending aorta resembles a paraboloid with 13∘ flow jet angle and non-null in-plane velocity.•Principal component analysis unveiled the main flow features responsible for 4D velocity profile variability.•A new standard is set for the computational bioengineering community, replacing idealized inflow boundary conditions in numerical simulations of blood flow with more realistic conditions.•We provide the generated synthetic cohort of 4D velocity profiles ready to be used by the scientific community for time-dependent CFD simulations.