Genomic and Phenotypic Trait Variation of the Opportunistic Human Pathogen Aspergillus flavus and Its Close Relatives

E. Anne Hatmaker,Manuel Rangel-Grimaldo,Huzefa A. Raja,Hadi Pourhadi,Sonja L. Knowles,Kevin Fuller,Emily M. Adams,Jorge D. Lightfoot,Rafael W. Bastos,Gustavo H. Goldman,Nicholas H. Oberlies,Antonis Rokas

Microbiology Spectrum（2022）

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摘要

Aspergillus flavus is a filamentous fungus that causes opportunistic human infections, such as aspergillosis and fungal keratitis, but its close relatives are considered nonpathogenic. To begin understanding how this difference in pathogenicity evolved, we characterized variation in infection-relevant genomic, chemical, and phenotypic traits between strains of A. flavus and its relatives.

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Aspergillus flavus,aspergillosis,biosynthetic gene cluster,comparative genomics,evolution,fungal keratitis,genomes,genomics,pathogenicity,phenotypic variation,secondary metabolism,secondary metabolites

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