Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-cell acute lymphoblastic leukemia

Patrizio Panelli,Elisabetta De Santis,Mattia Colucci,Francesco Tamiro,Francesca Sansico,Mattia Miroballo,Emanuele Murgo,Costanzo Padovano,Sam Gusscott,Michele Ciavarella,Elizabeth A. Chavez,Fabrizio Bianchi,Giovanni Rossi,Angelo M. Carella,Christian Steidl,Andrew P. Weng,Vincenzo Giambra

Blood（2023）

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摘要

•Noncanonical interactions of β-catenin with FOXO3 transcription factor promote LIC activity in early T-cell precursor ALL.•β-Catenin– and FOXO3-dependent gene signature identifies LIC-enriched CD82+CD117+ cell subsets, highly selected in MRD.

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leukemia-initiating,t-cell

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