NRG1/ErbB2 axis regulated mitochondrial function and antioxidant enzymes of neural stem cells in the cochlear nucleus partially through PGC-1α

Jian Wang,Li Wei,Keyong Tian,Min Xu,Xiaodong Chen,Fuquan Chen,Dingjun Zha,Tao Xue

Neuroscience Letters（2023）

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摘要

•ErbB2 knockdown reduced the antioxidant enzymes in NSCs treated by NRG1.•ErbB2 knockdown suppressed expression of mitochondrial biogenesis-associated genes.•PGC-1α signaling mediated the effects of the NRG1/ErbB2 axis in NSCs.

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关键词

NRG1/ErbB2 axis,Neural stem cells,Cochlear nucleus,Mitochondrial biogenesis,Mitochondrial function,PGC-1α

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